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  B1.1   Scientific Inquiry
    B1.1A Generate new questions that can be investigated in the laboratory or field.
    B1.1B Evaluate the uncertainties or validity of scientific conclusions using an understanding of sources of measurement error, the challenges of controlling variables, accuracy of data analysis, logic of argument, logic of experimental design, and/or the dependence on underlying assumptions.
    B1.1C Conduct scientific investigations using appropriate tools and techniques (e.g., selecting an instrument that measures the desired quantity—length, volume, weight, time interval, temperature—with the appropriate level of precision).
    B1.1D Identify patterns in data and relate them to theoretical models.
    B1.1E Describe a reason for a given conclusion using evidence from an investigation.
    B1.1f Predict what would happen if the variables, methods, or timing of an investigation were changed.
    B1.1g Use empirical evidence to explain and critique the reasoning used to draw a scientific conclusion or explanation.
    B1.1h Design and conduct a systematic scientific investigation that tests a hypothesis. Draw conclusions from data presented in charts or tables.
    B1.1i Distinguish between scientific explanations that are regarded as current scientific consensus and the emerging questions that active researchers investigate.
  B1.2   Scientific Reflection and Social Implications
    B1.2A Critique whether or not specific questions can be answered through scientific investigations.
    B1.2B Identify and critique arguments about personal or societal issues based on scientific evidence.
    B1.2C Develop an understanding of a scientific concept by accessing information from multiple sources. Evaluate the scientific accuracy and significance of the information.
    B1.2D Evaluate scientific explanations in a peer review process or discussion format.
    B1.2E Evaluate the future career and occupational prospects of science fields.
    B1.2f Critique solutions to problems, given criteria and scientific constraints.
    B1.2g Identify scientific tradeoffs in design decisions and choose among alternative solutions.
    B1.2h Describe the distinctions between scientific theories, laws, hypotheses, and observations.
    B1.2i Explain the progression of ideas and explanations that leads to science theories that are part of the current scientific consensus or core knowledge.
    B1.2j Apply science principles or scientific data to anticipate effects of technological design decisions.
    B1.2k Analyze how science and society interact from a historical, political, economic, or social perspective.
  L2.p1   Cells
    L2.p1A Distinguish between living and nonliving systems.
    L2.p1B Explain the importance of both water and the element carbon to cells.
    L2.p1C Describe growth and development in terms of increase in cell number, cell size, and/or cell products.
    L2.p1D Explain how the systems in a multicellular organism work together to support the organism.
    L2.p1E Compare and contrast how different organisms accomplish similar functions (e.g., obtain oxygen for respiration, and excrete waste).
  L2.p2   Cell Function
    L2.p2A Describe how organisms sustain life by obtaining, transporting, transforming, releasing, and eliminating matter and energy.
    L2.p2B Describe the effect of limiting food to developing cells.
  L2.p3   Plants as Producers
    L2.p3A Explain the significance of carbon in organic molecules.
    L2.p3B Explain the origins of plant mass.
    L2.p3C Predict what would happen to plants growing in low carbon dioxide atmospheres.
    L2.p3D Explain how the roots of specific plants grow.
  L2.p4   Animals as Consumers
    L2.p4A Classify different organisms based on how they obtain energy for growth and development.
    L2.p4B Explain how an organism obtains energy from the food it consumes.
  L2.p5   Common Elements
    L2.p5A Recognize the six most common elements in organic molecules (C, H, N, O, P, S).
    L2.p5B Identify the most common complex molecules that make up living organisms.
    L2.p5C Predict what would happen if essential elements were withheld from developing cells.
  B2.1   Transformation of Matter and Energy in Cells
    B2.1A Explain how cells transform energy (ultimately obtained from the sun) from one form to another through the processes of photosynthesis and respiration. Identify the reactants and products in the general reaction of photosynthesis.
    B2.1B Compare and contrast the transformation of matter and energy during photosynthesis and respiration.
    B2.1C Explain cell division, growth, and development as a consequence of an increase in cell number, cell size, and/or cell products.
  B2.1x   Cell Differentiation
    B2.1d Describe how, through cell division, cells can become specialized for specific function.
    B2.1e Predict what would happen if the cells from one part of a developing embryo were transplanted to another part of the embryo.
  B2.2   Organic Molecules
    B2.2A Explain how carbon can join to other carbon atoms in chains and rings to form large and complex molecules.
    B2.2B Recognize the six most common elements in organic molecules (C, H, N, O, P, S).
    B2.2C Describe the composition of the four major categories of organic molecules (carbohydrates, lipids, proteins, and nucleic acids).
    B2.2D Explain the general structure and primary functions of the major complex organic molecules that compose living organisms.
    B2.2E Describe how dehydration and hydrolysis relate to organic molecules.
  B2.2x   Proteins
    B2.2f Explain the role of enzymes and other proteins in biochemical functions (e.g., the protein hemoglobin carries oxygen in some organisms, digestive enzymes, and hormones).
    B2.2g Propose how moving an organism to a new environment may influence its ability to survive and predict the possible impact of this type of transfer.
  B2.3   Maintaining Environmental Stability
    B2.3A Describe how cells function in a narrow range of physical conditions, such as temperature and pH (acidity), to perform life functions.
    B2.3B Describe how the maintenance of a relatively stable internal environment is required for the continuation of life.
    B2.3C Explain how stability is challenged by changing physical, chemical, and environmental conditions as well as the presence of disease agents.
  B2.3x   Homeostasis
    B2.3d Identify the general functions of the major systems of the human body (digestion, respiration, reproduction, circulation, excretion, protection from disease, and movement, control, and coordination) and describe ways that these systems interact with each other.
    B2.3e Describe how human body systems maintain relatively constant internal conditions (temperature, acidity, and blood sugar).
    B2.3f Explain how human organ systems help maintain human health.
    B2.3g Compare the structure and function of a human body system or subsystem to a nonliving system (e.g., human joints to hinges, enzyme and substrate to interlocking puzzle pieces).
  B2.4   Cell Specialization
    B2.4A Explain that living things can be classified based on structural, embryological, and molecular (relatedness of DNA sequence) evidence.
    B2.4B Describe how various organisms have developed different specializations to accomplish a particular function and yet the end result is the same (e.g., excreting nitrogenous wastes in animals, obtaining oxygen for respiration).
    B2.4C Explain how different organisms accomplish the same result using different structural specializations (gills vs. lungs vs. membranes).
    B2.4d Analyze the relationships among organisms based on their shared physical, biochemical, genetic, and cellular characteristics and functional processes.
    B2.4e Explain how cellular respiration is important for the production of ATP (build on aerobic vs. anaerobic).
    B2.4f Recognize and describe that both living and nonliving things are composed of compounds, which are themselves made up of elements joined by energy-containing bonds, such as those in ATP.
    B2.4g Explain that some structures in the modern eukaryotic cell developed from early prokaryotes, such as mitochondria, and in plants, chloroplasts.
    B2.4h Describe the structures of viruses and bacteria.
    B2.4i Recognize that while viruses lack cellular structure, they have the genetic material to invade living cells.
  B2.5   Living Organism Composition
    B2.5A Recognize and explain that macromolecules such as lipids contain high energy bonds.
    B2.5B Explain how major systems and processes work together in animals and plants, including relationships between organelles, cells, tissues, organs, organ systems, and organisms. Relate these to molecular functions.
    B2.5C Describe how energy is transferred and transformed from the Sun to energy-rich molecules during photosynthesis.
    B2.5D Describe how individual cells break down energy-rich molecules to provide energy for cell functions.
  B2.5x   Energy Transfer
    B2.5e Explain the interrelated nature of photosynthesis and cellular respiration in terms of ATP synthesis and degradation.
    B2.5f Relate plant structures and functions to the process of photosynthesis and respiration.
    B2.5g Compare and contrast plant and animal cells.
    B2.5h Explain the role of cell membranes as a highly selective barrier (diffusion, osmosis, and active transport).
    B2.5i Relate cell parts/organelles to their function.
  B2.6x   Internal/External Cell Regulation
    B2.6a Explain that the regulatory and behavioral responses of an organism to external stimuli occur in order to maintain both short- and long-term equilibrium.
    B2.r6b Explain that complex interactions among the different kinds of molecules in the cell cause distinct cycles of activities, such as growth and division. Note that cell behavior can also be affected by molecules from other parts of the organism, such as hormones. (recommended)
    B2.r6c Recognize and explain that communication and/or interaction are required between cells to coordinate their diverse activities. (recommended)
    B2.r6d Explain how higher levels of organization result from specific complex interactions of smaller units and that their maintenance requires a constant input of energy as well as new material. (recommended)
    B2.r6e Analyze the body’s response to medical interventions such as organ transplants, medicines, and inoculations. (recommended)
  L3.p1   Populations, Communities, and Ecosystems
    L3.p1A Provide examples of a population, community, and ecosystem.
  L3.p2   Relationships Among Organisms
    L3.p2A Describe common relationships among organisms and provide examples of producer/consumer, predator/prey, or parasite/host relationship.
    L3.p2B Describe common ecological relationships between and among species and their environments (competition, territory, carrying capacity, natural balance, population, dependence, survival, and other biotic and abiotic factors).
    L3.p2C Describe the role of decomposers in the transfer of energy in an ecosystem.
    L3.p2D Explain how two organisms can be mutually beneficial and how that can lead to interdependency.
  L3.p3   Factors Influencing Ecosystems
    L3.p3A Identify the factors in an ecosystem that influence fluctuations in population size.
    L3.p3B Distinguish between the living (biotic) and nonliving (abiotic) components of an ecosystem.
    L3.p3C Explain how biotic and abiotic factors cycle in an ecosystem (water, carbon, oxygen, and nitrogen).
    L3.p3D Predict how changes in one population might affect other populations based upon their relationships in a food web.
  L3.p4   Human Impact on Ecosystems
    L3.p4A Recognize that, and describe how, human beings are part of Earth’s ecosystems. Note that human activities can deliberately or inadvertently alter the equilibrium in ecosystems.
  B3.1   Photosynthesis and Respiration
    B3.1A Describe how organisms acquire energy directly or indirectly from sunlight.
    B3.1B Illustrate and describe the energy conversions that occur during photosynthesis and respiration.
    B3.1C Recognize the equations for photosynthesis and respiration and identify the reactants and products for both.
    B3.1D Explain how living organisms gain and use mass through the processes of photosynthesis and respiration.
    B3.1e Write the chemical equation for photosynthesis and cellular respiration and explain in words what they mean.
    B3.1f Summarize the process of photosynthesis.
  B3.2   Ecosystems
    B3.2A Identify how energy is stored in an ecosystem.
    B3.2B Describe energy transfer through an ecosystem, accounting for energy lost to the environment as heat.
    B3.2C Draw the flow of energy through an ecosystem. Predict changes in the food web when one or more organisms are removed.
  B3.3   Element Recombination
    B3.3A Use a food web to identify and distinguish producers, consumers, and decomposers and explain the transfer of energy through trophic levels.
    B3.3b Describe environmental processes (e.g., the carbon and nitrogen cycles) and their role in processing matter crucial for sustaining life.
  B3.4   Changes in Ecosystems
    B3.4A Describe ecosystem stability. Understand that if a disaster such as flood or fire occurs, the damaged ecosystem is likely to recover in stages of succession that eventually result in a system similar to the original one.
    B3.4B Recognize and describe that a great diversity of species increases the chance that at least some living organisms will survive in the face of cataclysmic changes in the environment.
    B3.4C Examine the negative impact of human activities.
  B3.4x   Human Impact
    B3.4d Describe the greenhouse effect and list possible causes.
    B3.4e List the possible causes and consequences of global warming.
  B3.5   Populations
    B3.5A Graph changes in population growth, given a data table.
    B3.5B Explain the influences that affect population growth.
    B3.5C Predict the consequences of an invading organism on the survival of other organisms.
  B3.5x   Environmental Factors
    B3.5d Describe different reproductive strategies employed by various organisms and explain their advantages and disadvantages.
    B3.5e Recognize that and describe how the physical or chemical environment may influence the rate, extent, and nature of population dynamics within ecosystems.
    B3.5f Graph an example of exponential growth. Then show the population leveling off at the carrying capacity of the environment.
    B3.r5g Diagram and describe the stages of the life cycle for a human disease-causing organism. (recommended)
  L4.p1   Reproduction
    L4.p1A Compare and contrast the differences between sexual and asexual reproduction.
    L4.p1B Discuss the advantages and disadvantages of sexual vs. asexual reproduction.
  L4.p2   Heredity and Environment
    L4.p2A Explain that the traits of an individual are influenced by both the environment and the genetics of the individual. Acquired traits are not inherited; only genetic traits are inherited.
  B4.1   Genetics and Inherited Traits
    B4.1A Draw and label a homologous chromosome pair with heterozygous alleles highlighting a particular gene location.
    B4.1B Explain that the information passed from parents to offspring is transmitted by means of genes that are coded in DNA molecules. These genes contain the information for the production of proteins.
    B4.1c Differentiate between dominant, recessive, codominant, polygenic, and sex-linked traits.
    B4.1d Explain the genetic basis for Mendel’s laws of segregation and independent assortment.
    B4.1e Determine the genotype and phenotype of monohybrid crosses using a Punnett Square.
  B4.2   DNA
    B4.2A Show that when mutations occur in sex cells, they can be passed on to offspring (inherited mutations), but if they occur in other cells, they can be passed on to descendant cells only (noninherited mutations).
    B4.2B Recognize that every species has its own characteristic DNA sequence.
    B4.2C Describe the structure and function of DNA.
    B4.2D Predict the consequences that changes in the DNA composition of particular genes may have on an organism (e.g., sickle cell anemia, other).
    B4.2E Propose possible effects (on the genes) of exposing an organism to radiation and toxic chemicals.
  B4.2x   DNA, RNA, and Protein Synthesis
    B4.2f Demonstrate how the genetic information in DNA molecules provides instructions for assembling protein molecules and that this is virtually the same mechanism for all life forms.
    B4.2g Describe the processes of replication, transcription, and translation and how they relate to each other in molecular biology.
    B4.2h Recognize that genetic engineering techniques provide great potential and responsibilities.
    B4.r2i Explain how recombinant DNA technology allows scientists to analyze the structure and function of genes. (recommended)
  B4.3   Cell Division — Mitosis and Meiosis
    B4.3A Compare and contrast the processes of cell division (mitosis and meiosis), particularly as those processes relate to production of new cells and to passing on genetic information between generations.
    B4.3B Explain why only mutations occurring in gametes (sex cells) can be passed on to offspring.
    B4.3C Explain how it might be possible to identify genetic defects from just a karyotype of a few cells.
    B4.3d Explain that the sorting and recombination of genes in sexual reproduction result in a great variety of possible gene combinations from the offspring of two parents.
    B4.3e Recognize that genetic variation can occur from such processes as crossing over, jumping genes, and deletion and duplication of genes.
    B4.3f Predict how mutations may be transferred to progeny.
    B4.3g Explain that cellular differentiation results from gene expression and/or environmental influence (e.g., metamorphosis, nutrition).
  B4.4x   Genetic Variation
    B4.4a Describe how inserting, deleting, or substituting DNA segments can alter a gene. Recognize that an altered gene may be passed on to every cell that develops from it and that the resulting features may help, harm, or have little or no effect on the offspring’s success in its environment.
    B4.4b Explain that gene mutation in a cell can result in uncontrolled cell division called cancer. Also know that exposure of cells to certain chemicals and radiation increases mutations and thus increases the chance of cancer.
    B4.4c Explain how mutations in the DNA sequence of a gene may be silent or result in phenotypic change in an organism and in its offspring.
  B4.r5   x Recombinant DNA
    B4.r5a Explain how recombinant DNA technology allows scientists to analyze the structure and function of genes. (recommended)
    B4.r5b Evaluate the advantages and disadvantages of human manipulation of DNA. (recommended)
  L5.p1   Survival and Extinction
    L5.p1A Define a species and give examples.
    L5.p1B Define a population and identify local populations.
    L5.p1C Explain how extinction removes genes from the gene pool.
    L5.p1D Explain the importance of the fossil record.
  L5.p2   Classification
    L5.p2A Explain, with examples, that ecology studies the varieties and interactions of living things across space while evolution studies the varieties and interactions of living things across time.
  B5.1   Theory of Evolution
    B5.1A Summarize the major concepts of natural selection (differential survival and reproduction of chance inherited variants, depending on environmental conditions).
    B5.1B Describe how natural selection provides a mechanism for evolution.
    B5.1c Summarize the relationships between present-day organisms and those that inhabited the Earth in the past (e.g., use fossil record, embryonic stages, homologous structures, chemical basis).
    B5.1d Explain how a new species or variety originates through the evolutionary process of natural selection.
    B5.1e Explain how natural selection leads to organisms that are well suited for the environment (differential survival and reproduction of chance inherited variants, depending upon environmental conditions).
    B5.1f Explain, using examples, how the fossil record, comparative anatomy, and other evidence supports the theory of evolution.
    B5.1g Illustrate how genetic variation is preserved or eliminated from a population through natural selection (evolution) resulting in biodiversity.
  B5.2x   Molecular Evidence
    B5.2a Describe species as reproductively distinct groups of organisms that can be classified based on morphological, behavioral, and molecular similarities.
    B5.2b Explain that the degree of kinship between organisms or species can be estimated from the similarity of their DNA and protein sequences.
    B5.2c Trace the relationship between environmental changes and changes in the gene pool, such as genetic drift and isolation of subpopulations.
    B5.r2d Interpret a cladogram or phylogenetic tree showing evolutionary relationships among organisms. (recommended)
  B5.3   Natural Selection
    B5.3A Explain how natural selection acts on individuals, but it is populations that evolve. Relate genetic mutations and genetic variety produced by sexual reproduction to diversity within a given population.
    B5.3B Describe the role of geographic isolation in speciation.
    B4.3C Give examples of ways in which genetic variation and environmental factors are causes of evolution and the diversity of organisms.
    B5.3d Explain how evolution through natural selection can result in changes in biodiversity.
    B5.3e Explain how changes at the gene level are the foundation for changes in populations and eventually the formation of new species.
    B5.3f Demonstrate and explain how biotechnology can improve a population and species.